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Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP
Dnmt1 is frequently overexpressed in cancers, which contributes significantly to cancer-associated epigenetic silencing of tumor suppressor genes. However, the mechanism of Dnmt1 overexpression remains elusive. Herein, we elucidate a pathway through which nuclear receptor SHP inhibits zinc-dependent...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367194/ https://ncbi.nlm.nih.gov/pubmed/22362755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks159 |
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