Selective Increase of Two ABC Drug Efflux Transporters at the Blood-Spinal Cord Barrier Suggests Induced Pharmacoresistance in ALS

ATP-binding cassette (ABC) drug efflux transporters in the CNS are predominantly localized to the luminal surface of endothelial cells in capillaries to impede CNS accumulation of xenobiotics. Inflammatory mediators and cellular stressors regulate their activity. Amyotrophic lateral sclerosis (ALS)...

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Autori principali: Jablonski, Michael R., Jacob, Dena A., Campos, Christopher, Miller, David S., Maragakis, Nicholas J., Pasinelli, Piera, Trotti, Davide
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367047/
https://ncbi.nlm.nih.gov/pubmed/22521463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.03.040
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