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Dendritic cell activating vaccine adjuvants differ in the ability to elicit anti-tumor immunity due to an adjuvant specific induction of immune suppressive cells

PURPOSE: We questioned whether the vaccine adjuvant combination of TLR7 ligand agonist, imiquimod, with GM-CSF would result in enhanced dendritic cell recruitment and activation with increased antigen-specific immunity as compared with either adjuvant used alone. EXPERIMENTAL DESIGN: The adjuvant ef...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Dang, Yushe, Wagner, Wolfgang M., Gad, Ekram, Rastetter, Lauren, Berger, Carmen M., Holt, Gregory E., Disis, Mary L.
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2012
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3367040/ https://ncbi.nlm.nih.gov/pubmed/22510348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0113
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Dendritic cell activating vaccine adjuvants differ in the ability to elicit anti-tumor immunity due to an adjuvant specific induction of immune suppressive cells

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