Immunization against HIF-1α inhibits the growth of basal mammary tumors and targets mammary stem cells in vivo

PURPOSE: Triple negative breast cancer (TNBC) represents a cancer stem cell enriched phenotype. Hypoxia-inducible factor-1 alpha (HIF-1α) induces the expression of proteins associated with stemness and is highly upregulated in TNBC. We questioned whether HIF-1α was immunogenic and whether vaccinatio...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Cecil, Denise L., Slota, Meredith, O’Meara, Megan M., Curtis, Benjamin C., Gad, Ekram, Dang, Yushe, Herendeen, Daniel, Rastetter, Lauren, Disis, Mary L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493515/
https://ncbi.nlm.nih.gov/pubmed/28039264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1678
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