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Phosphoramidate analogues of DNA: synthesis and thermal stability of heteroduplexes.

The deoxyoligonucleotide 5' AATCGGGCATGGATT (15-mer) was synthesized containing 12 phosphoramidate linkages derived from 2 primary and 2 secondary amines. The oligonucleotides were purified by reverse phase HPLC and characterized by PAGE. The thermal stability of the duplexes derived from these...

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Bibliografske podrobnosti
Main Authors: Froehler, B, Ng, P, Matteucci, M
Format: Artigo
Jezik:Inglês
Izdano: 1988
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC336699/
https://ncbi.nlm.nih.gov/pubmed/3387210
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