G Protein-coupled Receptor Kinase 5 Phosphorylates Nucleophosmin and Regulates Cell Sensitivity to Polo-like Kinase 1 Inhibition

G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, leading to their desensitization and endocytosis. GRKs have also been implicated in phosphorylating other classes of proteins and can localize in a variety of cellular compartments, including the nucleus....

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Bibliographic Details
Main Authors: So, Christopher H., Michal, Allison M., Mashayekhi, Rouzbeh, Benovic, Jeffrey L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366848/
https://ncbi.nlm.nih.gov/pubmed/22467873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353854
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