Loss of T Regulatory Cell Suppression following Signaling through Glucocorticoid-induced Tumor Necrosis Receptor (GITR) Is Dependent on c-Jun N-terminal Kinase Activation

Naturally occurring Foxp3(+)CD4(+)CD25(+) T regulatory cell (nTreg)-mediated suppression of lung allergic responses is abrogated following ligation of glucocorticoid-induced tumor necrosis receptor (GITR) family-related protein. In vitro stimulation of nTregs with GITR ligand increased phosphorylati...

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Autori principali: Joetham, Anthony, Ohnishi, Hiroshi, Okamoto, Masakazu, Takeda, Katsuyuki, Schedel, Michaela, Domenico, Joanne, Dakhama, Azzeddine, Gelfand, Erwin W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366833/
https://ncbi.nlm.nih.gov/pubmed/22461627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.316943
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