Selective Gα(i) Subunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels

The ubiquitous transient receptor potential canonical (TRPC) channels function as non-selective, Ca(2+)-permeable channels and mediate numerous cellular functions. It is commonly assumed that TRPC channels are activated by stimulation of Gα(q)-PLC-coupled receptors. However, whether the Gα(q)-PLC pa...

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Detalhes bibliográficos
Main Authors: Jeon, Jae-Pyo, Hong, Chansik, Park, Eun Jung, Jeon, Ju-Hong, Cho, Nam-Hyuk, Kim, In-Gyu, Choe, Han, Muallem, Shmuel, Kim, Hyun Jin, So, Insuk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366817/
https://ncbi.nlm.nih.gov/pubmed/22457348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.326553
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