Oxidatively Truncated Phospholipids Are Required Agents of Tumor Necrosis Factor α (TNFα)-induced Apoptosis

TNFα generates reactive oxygen species (ROS) at the cell surface that induce cell death, but how ROS communicate to mitochondria and their specific apoptotic action(s) are both undefined. ROS oxidize phospholipids to hydroperoxides that are friable and fragment adjacent to the (hydro)peroxide functi...

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Bibliographic Details
Main Authors: Latchoumycandane, Calivarathan, Marathe, Gopal K., Zhang, Renliang, McIntyre, Thomas M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366783/
https://ncbi.nlm.nih.gov/pubmed/22433871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300012
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