Casein Kinase 2-mediated Synaptic GluN2A Up-regulation Increases N-Methyl-d-aspartate Receptor Activity and Excitability of Hypothalamic Neurons in Hypertension

Increased glutamatergic input, particularly N-methyl-d-aspartate receptor (NMDAR) activity, in the paraventricular nucleus (PVN) of the hypothalamus is closely associated with high sympathetic outflow in essential hypertension. The molecular mechanisms underlying augmented NMDAR activity in hyperten...

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Main Authors: Ye(叶, Zeng-You, 增友), Li(李, Li, 莉), Li(李, De-Pei, 德培), Pan(潘, Hui-Lin, 惠麟)
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366779/
https://ncbi.nlm.nih.gov/pubmed/22474321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.331165
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