Tumors with Nonfunctional Retinoblastoma Protein Are Killed by Reduced γ-Tubulin Levels

In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ-tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ-tubulin protein level...

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Hauptverfasser: Ehlén, Åsa, Rosselló, Catalina A., von Stedingk, Kristoffer, Höög, Greta, Nilsson, Elise, Pettersson, Helen M., Jirström, Karin, Alvarado-Kristensson, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366773/
https://ncbi.nlm.nih.gov/pubmed/22493456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357038
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