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Tumors with Nonfunctional Retinoblastoma Protein Are Killed by Reduced γ-Tubulin Levels
In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ-tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ-tubulin protein level...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366773/ https://ncbi.nlm.nih.gov/pubmed/22493456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357038 |
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