Physical contact with endothelial cells through β1- and β2- integrins rescues chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis and induces a peculiar gene expression profile in leukemic cells

BACKGROUND: Chronic lymphocytic leukemia B cells display prolonged survival in vivo, but when cultured in vitro rapidly undergo spontaneous apoptosis. We hypothesize that interactions with endothelial cells in infiltrated tissues and during recirculation may have a pathogenic role in chronic lymphoc...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Maffei, Rossana, Fiorcari, Stefania, Bulgarelli, Jenny, Martinelli, Silvia, Castelli, Ilaria, Deaglio, Silvia, Debbia, Giulia, Fontana, Marcella, Coluccio, Valeria, Bonacorsi, Goretta, Zucchini, Patrizia, Narni, Franco, Torelli, Giuseppe, Luppi, Mario, Marasca, Roberto
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Ferrata Storti Foundation 2012
विषय:
Original Articles and Brief Reports
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366665/
https://ncbi.nlm.nih.gov/pubmed/22207686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.054924
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