Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis

Telomere shortening limits the proliferative capacity of a cell, but perhaps surprisingly, shortening is also known to be associated with increased rates of tumor initiation. A current hypothesis suggests that telomere dysfunction increases tumor initiation by induction of chromosomal instability, b...

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Dades bibliogràfiques
Autors principals: Begus-Nahrmann, Yvonne, Hartmann, Daniel, Kraus, Johann, Eshraghi, Parisa, Scheffold, Annika, Grieb, Melanie, Rasche, Volker, Schirmacher, Peter, Lee, Han-Wong, Kestler, Hans A., Lechel, André, Rudolph, K. Lenhard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2012
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366409/
https://ncbi.nlm.nih.gov/pubmed/22622037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61745
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