Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all cancers and shows remarkable resistance to cell stress. Nuclear protein 1 (Nupr1), which mediates stress response in the pancreas, is frequently upregulated in pancreatic cancer. Here, we report that Nupr1 plays an essential...

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Bibliographic Details
Main Authors: Hamidi, Tewfik, Algül, Hana, Cano, Carla Eliana, Sandi, Maria José, Molejon, Maria Inés, Riemann, Marc, Calvo, Ezequiel Luis, Lomberk, Gwen, Dagorn, Jean-Charles, Weih, Falk, Urrutia, Raul, Schmid, Roland Michael, Iovanna, Juan Lucio
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366404/
https://ncbi.nlm.nih.gov/pubmed/22565310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60144
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