Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all cancers and shows remarkable resistance to cell stress. Nuclear protein 1 (Nupr1), which mediates stress response in the pancreas, is frequently upregulated in pancreatic cancer. Here, we report that Nupr1 plays an essential...

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Detalhes bibliográficos
Main Authors: Hamidi, Tewfik, Algül, Hana, Cano, Carla Eliana, Sandi, Maria José, Molejon, Maria Inés, Riemann, Marc, Calvo, Ezequiel Luis, Lomberk, Gwen, Dagorn, Jean-Charles, Weih, Falk, Urrutia, Raul, Schmid, Roland Michael, Iovanna, Juan Lucio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366404/
https://ncbi.nlm.nih.gov/pubmed/22565310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60144
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