Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies

Fanconi anemia (FA) is the most common inherited bone marrow failure syndrome. FA patients suffer to varying degrees from a heterogeneous range of developmental defects and, in addition, have an increased likelihood of developing cancer. Almost all FA patients develop a severe, progressive bone marr...

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Autors principals: Geiselhart, Anja, Lier, Amelie, Walter, Dagmar, Milsom, Michael D.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2012
Matèries:
Review Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366203/
https://ncbi.nlm.nih.gov/pubmed/22675615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/265790
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