Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore microtubule attachment

Cdt1, a protein critical for replication origin licensing in G1 phase is degraded during S phase but re-accumulates in G2 phase. We now demonstrate that human Cdt1 has a separable essential mitotic function. Cdt1 localizes to kinetochores during mitosis through interaction with the Hec1 component of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Varma, Dileep, Chandrasekaran, Srikripa, Sundin, Lynsie J. R., Reidy, Karen T., Wan, Xiaohu, Chasse, Dawn A. D., Nevis, Kathleen R., DeLuca, Jennifer G., Salmon, E. D., Cook, Jeanette Gowen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366049/
https://ncbi.nlm.nih.gov/pubmed/22581055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2489
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