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Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal

Synthesis of truncated androgen receptor (AR) splice variants has emerged as an important mechanism of prostate cancer (PCa) resistance to AR-targeted therapy and progression to a lethal castration-resistant phenotype. However, the precise role of these factors at this stage of the disease is not cl...

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מידע ביבליוגרפי
Main Authors: Chan, Siu Chiu, Li, Yingming, Dehm, Scott M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366007/
https://ncbi.nlm.nih.gov/pubmed/22532567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352930
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