Human Heat Shock Protein 105/110 kDa (Hsp105/110) Regulates Biogenesis and Quality Control of Misfolded Cystic Fibrosis Transmembrane Conductance Regulator at Multiple Levels

Heat shock protein 105/110-kDa (Hsp105/110), a member of the Hsp70 super family of molecular chaperones, serves as a nucleotide exchange factor for Hsc70, independently prevents the aggregation of misfolded proteins, and functionally relates to Hsp90. We investigated the roles of human Hsp105α, the...

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Main Authors: Saxena, Anita, Banasavadi-Siddegowda, Yeshavanth K., Fan, Yifei, Bhattacharya, Sumit, Roy, Gargi, Giovannucci, David R., Frizzell, Raymond A., Wang, Xiaodong
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365948/
https://ncbi.nlm.nih.gov/pubmed/22505710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.297580
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