Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of “the dose makes the poison,” because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts i...

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Bibliografiske detaljer
Main Authors: Vandenberg, Laura N., Colborn, Theo, Hayes, Tyrone B., Heindel, Jerrold J., Jacobs, David R., Lee, Duk-Hee, Shioda, Toshi, Soto, Ana M., vom Saal, Frederick S., Welshons, Wade V., Zoeller, R. Thomas, Myers, John Peterson
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2012
Fag:
Reviews
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365860/
https://ncbi.nlm.nih.gov/pubmed/22419778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/er.2011-1050
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