Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of “the dose makes the poison,” because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts i...

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Detalhes bibliográficos
Main Authors: Vandenberg, Laura N., Colborn, Theo, Hayes, Tyrone B., Heindel, Jerrold J., Jacobs, David R., Lee, Duk-Hee, Shioda, Toshi, Soto, Ana M., vom Saal, Frederick S., Welshons, Wade V., Zoeller, R. Thomas, Myers, John Peterson
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Reviews
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365860/
https://ncbi.nlm.nih.gov/pubmed/22419778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/er.2011-1050
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