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PLZF Turns on the Effector T cell Program Without Requirement for Agonist TCR Signaling

Thymocytes expressing the NKT cell semi-invariant αβ TCR are thought to undergo agonist interactions with CD1d ligands prior to expressing PLZF, a BTB-POZ transcription factor that directs acquisition of the effector program of these innate-like T cells. Whether PLZF can mediate this effector conver...

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Detalhes bibliográficos
Main Authors: Savage, Adam K, Constantinides, Michael G., Bendelac, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365858/
https://ncbi.nlm.nih.gov/pubmed/21478405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100119
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