Stabilization of p53 in Influenza A Virus-infected Cells Is Associated with Compromised MDM2-mediated Ubiquitination of p53

Influenza A virus (IAV) induces apoptosis of infected cells. In response to IAV infection, p53, a tumor suppressor involved in regulating apoptosis and host antiviral defense, accumulates and becomes activated. This study was undertaken to examine the mechanism of p53 accumulation in IAV-infected ce...

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Autors principals: Wang, Xiaodu, Deng, Xufang, Yan, Wenjun, Zhu, Zixiang, Shen, Yang, Qiu, Yafeng, Shi, Zixue, Shao, Donghua, Wei, Jianchao, Xia, Xianzhu, Ma, Zhiyong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365762/
https://ncbi.nlm.nih.gov/pubmed/22474335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335422
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