Stretch-induced Fetal Type II Cell Differentiation Is Mediated via ErbB1-ErbB4 Interactions

Stretch-induced differentiation of lung fetal type II epithelial cells is mediated through EGFR (ErbB1) via release of HB-EGF and TGF-α ligands. Employing an EGFR knock-out mice model, we further investigated the role of the ErbB family of receptors in mechanotranduction during lung development. Del...

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Autors principals: Huang, Zheping, Wang, Yulian, Nayak, Pritha S., Dammann, Christiane E., Sanchez-Esteban, Juan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365737/
https://ncbi.nlm.nih.gov/pubmed/22493501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313163
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