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Mechanisms for Defining Supercoiling Set Point of DNA Gyrase Orthologs: I. A NONCONSERVED ACIDIC C-TERMINAL TAIL MODULATES ESCHERICHIA COLI GYRASE ACTIVITY

DNA topoisomerases manage chromosome supercoiling and organization in all cells. Gyrase, a prokaryotic type IIA topoisomerase, consumes ATP to introduce negative supercoils through a strand passage mechanism. All type IIA topoisomerases employ a similar set of catalytic domains for function; however...

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Bibliografske podrobnosti
Main Authors: Tretter, Elsa M., Berger, James M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365713/
https://ncbi.nlm.nih.gov/pubmed/22457353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345678
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