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Mechanisms for Defining Supercoiling Set Point of DNA Gyrase Orthologs: I. A NONCONSERVED ACIDIC C-TERMINAL TAIL MODULATES ESCHERICHIA COLI GYRASE ACTIVITY
DNA topoisomerases manage chromosome supercoiling and organization in all cells. Gyrase, a prokaryotic type IIA topoisomerase, consumes ATP to introduce negative supercoils through a strand passage mechanism. All type IIA topoisomerases employ a similar set of catalytic domains for function; however...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365713/ https://ncbi.nlm.nih.gov/pubmed/22457353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345678 |
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