Molecular Recognition of Candida albicans (1→2)-β-Mannan Oligosaccharides by a Protective Monoclonal Antibody Reveals the Immunodominance of Internal Saccharide Residues

A self-consistent model of β-mannan oligosaccharides bound to a monoclonal antibody, C3.1, that protects mice against Candida albicans has been developed through chemical mapping, NMR spectroscopic, and computational studies. This antibody optimally binds di- and trisaccharide epitopes, whereas larg...

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Bibliographic Details
Main Authors: Johnson, Margaret A., Cartmell, Jonathan, Weisser, Nina E., Woods, Robert J., Bundle, David R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365708/
https://ncbi.nlm.nih.gov/pubmed/22493450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355578
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