Excision of Trpv6 Gene Leads to Severe Defects in Epididymal Ca(2+) Absorption and Male Fertility Much Like Single D541A Pore Mutation

Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels in mice disrupts Ca(2+) absorption by the epididymal epithelium, resulting in abnormally high Ca(2+) concentrations in epididymal luminal fluid and in a dramatic but incomplete loss of sperm motility and fertilizat...

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Autores principales: Weissgerber, Petra, Kriebs, Ulrich, Tsvilovskyy, Volodymyr, Olausson, Jenny, Kretz, Oliver, Stoerger, Christof, Mannebach, Stefanie, Wissenbach, Ulrich, Vennekens, Rudi, Middendorff, Ralf, Flockerzi, Veit, Freichel, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365704/
https://ncbi.nlm.nih.gov/pubmed/22427671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328286
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