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Excision of Trpv6 Gene Leads to Severe Defects in Epididymal Ca(2+) Absorption and Male Fertility Much Like Single D541A Pore Mutation
Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels in mice disrupts Ca(2+) absorption by the epididymal epithelium, resulting in abnormally high Ca(2+) concentrations in epididymal luminal fluid and in a dramatic but incomplete loss of sperm motility and fertilizat...
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| Główni autorzy: | , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365704/ https://ncbi.nlm.nih.gov/pubmed/22427671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328286 |
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