Caricamento...

Binding Modes of Zaragozic Acid A to Human Squalene Synthase and Staphylococcal Dehydrosqualene Synthase

Zaragozic acids (ZAs) belong to a family of fungal metabolites with nanomolar inhibitory activity toward squalene synthase (SQS). The enzyme catalyzes the committed step of sterol synthesis and has attracted attention as a potential target for antilipogenic and antiinfective therapies. Here, we have...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Liu, Chia-I, Jeng, Wen-Yih, Chang, Wei-Jung, Ko, Tzu-Ping, Wang, Andrew H.-J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365694/
https://ncbi.nlm.nih.gov/pubmed/22474324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.351254
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !