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Binding Modes of Zaragozic Acid A to Human Squalene Synthase and Staphylococcal Dehydrosqualene Synthase

Zaragozic acids (ZAs) belong to a family of fungal metabolites with nanomolar inhibitory activity toward squalene synthase (SQS). The enzyme catalyzes the committed step of sterol synthesis and has attracted attention as a potential target for antilipogenic and antiinfective therapies. Here, we have...

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Bibliografske podrobnosti
Main Authors: Liu, Chia-I, Jeng, Wen-Yih, Chang, Wei-Jung, Ko, Tzu-Ping, Wang, Andrew H.-J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365694/
https://ncbi.nlm.nih.gov/pubmed/22474324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.351254
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