Significance of Calcium Binding, Tyrosine Phosphorylation, and Lysine Trimethylation for the Essential Function of Calmodulin in Vertebrate Cells Analyzed in a Novel Gene Replacement System

Calmodulin (CaM) was shown to be essential for survival of lower eukaryotes by gene deletion experiments. So far, no CaM gene deletion was reported in higher eukaryotes. In vertebrates, CaM is expressed from several genes, which encode an identical protein, making it difficult to generate a model sy...

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Autors principals: Panina, Svetlana, Stephan, Alexander, la Cour, Jonas M., Jacobsen, Kivin, Kallerup, Line K., Bumbuleviciute, Rasita, Knudsen, Kristoffer V. K., Sánchez-González, Pablo, Villalobo, Antonio, Olesen, Uffe H., Berchtold, Martin W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365693/
https://ncbi.nlm.nih.gov/pubmed/22493455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.339382
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