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Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1
Continuously dividing cells must be protected from telomeric and nontelomeric DNA damage in order to maintain their proliferative potential. Here, we report a novel telomere-protecting mechanism regulated by nucleostemin (NS). NS depletion increased the number of telomere damage foci in both telomer...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365494/ https://ncbi.nlm.nih.gov/pubmed/22641345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201109038 |
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