Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition

Helix-loop-helix (HLH) family transcription factors regulate numerous developmental and homeostatic processes. Dominant-negative HLH (dnHLH) proteins lack DNA-binding ability and capture basic HLH (bHLH) transcription factors to inhibit cellular differentiation and enhance cell proliferation and mot...

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Main Authors: Ishii, Ryohei, Isogaya, Kazunobu, Seto, Azusa, Koinuma, Daizo, Watanabe, Yuji, Arisaka, Fumio, Yaguchi, So-ichi, Ikushima, Hiroaki, Dohmae, Naoshi, Miyazono, Kohei, Miyazawa, Keiji, Ishitani, Ryuichiro, Nureki, Osamu
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365425/
https://ncbi.nlm.nih.gov/pubmed/22453338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.77
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