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Airway responsiveness depends on the diffusion rate of methacholine across the airway wall

During methacholine challenge tests of airway responsiveness, it is invariably assumed that the administered dose of agonist is accurately reflected in the dose that eventually reaches the airway smooth muscle (ASM). However, agonist must traverse a variety of tissue obstacles to reach the ASM, duri...

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Detalhes bibliográficos
Main Authors: Bates, Jason H. T., Stevenson, Chelsea A., Aliyeva, Minara, Lundblad, Lennart K. A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365406/
https://ncbi.nlm.nih.gov/pubmed/22383507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00703.2011
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