Brief Hyperoxia Increases Mitochondrial Oxidation and Increases Phosphodiesterase 5 Activity in Fetal Pulmonary Artery Smooth Muscle Cells

AIMS: Oxygen is a pulmonary vasodilator, but data suggest high O(2) concentrations impede that response. We previously reported 24 h of 100% O(2) increased phosphodiesterase 5 (PDE5) activity in fetal pulmonary artery smooth muscle cells (FPASMC) and in ventilated neonatal lambs. PDE5 degrades cycli...

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Autors principals: Farrow, Kathryn N., Lee, Keng Jin, Perez, Marta, Schriewer, Jacqueline M., Wedgwood, Stephen, Lakshminrusimha, Satyan, Smith, Cody L., Steinhorn, Robin H., Schumacker, Paul T.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2012
Matèries:
Original Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365357/
https://ncbi.nlm.nih.gov/pubmed/22229392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4184
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