KRASness and PIK3CAness in Patients with Advanced Colorectal Cancer: Outcome after Treatment with Early-Phase Trials with Targeted Pathway Inhibitors

PURPOSE: To evaluate clinicopathologic and molecular features of patients with metastatic colorectal cancer (mCRC) and their outcomes in early-phase trials using pathway-targeting agents. PATIENTS AND METHODS: We analyzed characteristics of 238 patients with mCRC referred to the phase 1 trials unit...

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Detalhes bibliográficos
Principais autores: Garrido-Laguna, Ignacio, Hong, David S., Janku, Filip, Nguyen, Ly M., Falchook, Gerald S., Fu, Siqing, Wheler, Jenifer J., Luthra, Rajyalakshmi, Naing, Aung, Wang, Xuemei, Kurzrock, Razelle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364990/
https://ncbi.nlm.nih.gov/pubmed/22675430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038033
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