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CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion
The proper maintenance of telomeres is essential for genome stability. Mammalian telomere maintenance is governed by a number of telomere binding proteins, including the newly identified CTC1–STN1–TEN1 (CST) complex. However, the in vivo functions of mammalian CST remain unclear. To address this que...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364752/ https://ncbi.nlm.nih.gov/pubmed/22531781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.96 |
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