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Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties

The origin and evolution of the complex regulatory landscapes of some vertebrate developmental genes, often spanning hundreds of Kbp and including neighboring genes, remain poorly understood. The Sonic Hedgehog (Shh) genomic regulatory block (GRB) is one of the best functionally characterized exampl...

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Detalles Bibliográficos
Main Authors: Irimia, Manuel, Royo, Jose L., Burguera, Demian, Maeso, Ignacio, Gómez-Skarmeta, José L., Garcia-Fernandez, Jordi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364491/
https://ncbi.nlm.nih.gov/pubmed/22666536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00433
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