Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome

BACKGROUND: Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping sur...

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Main Authors: Rodriguez-Frías, Francisco, Tabernero, David, Quer, Josep, Esteban, Juan I., Ortega, Israel, Domingo, Esteban, Cubero, Maria, Camós, Sílvia, Ferrer-Costa, Carles, Sánchez, Alex, Jardí, Rosendo, Schaper, Melanie, Homs, Maria, Garcia-Cehic, Damir, Guardia, Jaume, Esteban, Rafael, Buti, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364280/
https://ncbi.nlm.nih.gov/pubmed/22666402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037874
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