Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5

BACKGROUND: Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown antitumor activity in various cancer cells. Apo2 ligand or tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is regarded as a promising anticancer agent, but chemoresistance affec...

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Detalhes bibliográficos
Main Authors: Kong, Rui, Jia, Guang, Cheng, Zhuo-xin, Wang, Yong-wei, Mu, Ming, Wang, Shuang-jia, Pan, Shang-ha, Gao, Yue, Jiang, Hong-chi, Dong, De-li, Sun, Bei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364248/
https://ncbi.nlm.nih.gov/pubmed/22666346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037222
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