Universal influenza DNA vaccine encoding conserved CD4(+) T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice

The goal of the present study was to design a vaccine that would provide universal protection against infection of humans with diverse influenza A viruses. Accordingly, protein sequences from influenza A virus strains currently in circulation (H1N1, H3N2), agents of past pandemics (H1N1, H2N2, H3N2)...

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書誌詳細
主要な著者: Alexander, Jeff, Bilsel, Pamuk, del Guercio, Marie-France, Stewart, Stephani, Marinkovic-Petrovic, Aleksandra, Southwood, Scott, Crimi, Claire, Vang, Lo, Walker, Les, Ishioka, Glenn, Chitnis, Vivek, Sette, Alessandro, Assarsson, Erika, Hannaman, Drew, Botten, Jason, Newman, Mark J
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364000/
https://ncbi.nlm.nih.gov/pubmed/19895924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.10.103
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