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Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis
Mutation of the polarity gene Crumbs homolog 1 (CRB1) is responsible for >10% of Leber congenital amaurosis (LCA) cases worldwide; LCA is characterized by early-onset degenerative retinal dystrophy. The role of CRB1 in LCA8 pathogenesis remains elusive since Crb1 mouse mutants, including a null a...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3363335/ https://ncbi.nlm.nih.gov/pubmed/22398208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds091 |
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