Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis

Mutation of the polarity gene Crumbs homolog 1 (CRB1) is responsible for >10% of Leber congenital amaurosis (LCA) cases worldwide; LCA is characterized by early-onset degenerative retinal dystrophy. The role of CRB1 in LCA8 pathogenesis remains elusive since Crb1 mouse mutants, including a null a...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Cho, Seo-Hee, Kim, Jin Young, Simons, David L., Song, Ji Yun, Le, Julie H., Swindell, Eric C., Jamrich, Milan, Wu, Samuel M., Kim, Seonhee
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363335/
https://ncbi.nlm.nih.gov/pubmed/22398208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds091
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki