Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats

RATIONALE: Animal models of tobacco addiction rely on administration of nicotine alone or nicotine combined with isolated constituents. Models using tobacco extracts derived from tobacco products and containing a range of tobacco constituents might more accurately simulate tobacco exposure in humans...

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Bibliographic Details
Main Authors: Harris, Andrew C., Stepanov, Irina, Pentel, Paul R., LeSage, Mark G.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363290/
https://ncbi.nlm.nih.gov/pubmed/21960181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2514-y
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