Importance of highly selective LC–MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen

The antiestrogenic effect of tamoxifen is mainly attributable to the active metabolites endoxifen and 4-hydroxytamoxifen. This effect is assumed to be concentration-dependent and therefore quantitative analysis of tamoxifen and metabolites for clinical studies and therapeutic drug monitoring is incr...

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Main Authors: Jager, N. G. L., Rosing, H., Linn, S. C., Schellens, J. H. M., Beijnen, J. H.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2012
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362711/
https://ncbi.nlm.nih.gov/pubmed/22388692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2000-1
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