Synthesis and Biological Evaluation of Phenanthrenes as Cytotoxic Agents with Pharmacophore Modeling and ChemGPS-NP Prediction as Topo II Inhibitors

In a structure-activity relationship (SAR) study, 3-methoxy-1,4-phenanthrenequinones, calanquinone A (6a), denbinobin (6b), 5-OAc-calanquinone A (7a) and 5-OAc-denbinobin (7b), have significantly promising cytotoxicity against various human cancer cell lines (IC(50) 0.08–1.66 µg/mL). Moreover, we al...

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Detalhes bibliográficos
Main Authors: Lee, Chia-Lin, Lin, Ying-Ting, Chang, Fang-Rong, Chen, Guan-Yu, Backlund, Anders, Yang, Juan-Chang, Chen, Shu-Li, Wu, Yang-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362575/
https://ncbi.nlm.nih.gov/pubmed/22666407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037897
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