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Inhibition of Soluble Tumor Necrosis Factor Ameliorates Synaptic Alterations and Ca(2+) Dysregulation in Aged Rats

The role of tumor necrosis factor α (TNF) in neural function has been investigated extensively in several neurodegenerative conditions, but rarely in brain aging, where cognitive and physiologic changes are milder and more variable. Here, we show that protein levels for TNF receptor 1 (TNFR1) are si...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sama, Diana M., Mohmmad Abdul, Hafiz, Furman, Jennifer L., Artiushin, Irina A., Szymkowski, David E., Scheff, Stephen W., Norris, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362564/
https://ncbi.nlm.nih.gov/pubmed/22666474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038170
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