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Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

Using a quantitative electron microscopic autoradiographic technique, we have localized the initial binding step of 125I-labeled epidermal growth factor (125I-EGF) to the plasma membrane of the human fibroblast. After initial binding, labeled EGF is internalized progressively by the cell in a time-...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gorden, P, Carpentier, J L, Cohen, S, Orci, L
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1978
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC336255/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/311005/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.10.5025
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