WT1 silencing by RNAi synergizes with chemotherapeutic agents and induces chemosensitization to doxorubicin and cisplatin in B16F10 murine melanoma cells

The Wilm's tumor gene (WT1), encoding a transcription factor that modulates the expression of certain genes that are involved in proliferation and apoptosis, is overexpressed in numerous solid tumors. WT1 is important for cell proliferation and in the diagnosis of melanoma. The objectives of th...

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Detalhes bibliográficos
Main Authors: Zapata-Benavides, Pablo, Manilla-Muñoz, Edgar, Zamora-Avila, Diana E., Saavedra-Alonso, Santiago, Franco-Molina, Moisés A., Trejo-Avila, Laura M., Davalos-Aranda, Guillermo, Rodríguez-Padilla, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362395/
https://ncbi.nlm.nih.gov/pubmed/22740987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.578
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