Sequences of a hairpin structure in the 3′-untranslated region mediate regulation of human pulmonary surfactant protein B mRNA stability

The ability of pulmonary surfactant to reduce alveolar surface tension requires adequate expression of surfactant protein B (SP-B). Dexamethasone (DEX, 10(−7) M) increases human SP-B mRNA stability by a mechanism that requires a 126-nt-long segment (the 7.6S region) of the 3′-untranslated region (3′...

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Detalhes bibliográficos
Main Authors: Huang, Helen W., Payne, David E., Bi, Weizhen, Pan, Su, Bruce, Shirley R., Alcorn, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362263/
https://ncbi.nlm.nih.gov/pubmed/22367784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00015.2012
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